Overview Of The Project
Lancaster University’s Division of Biomedical and Life Sciences seeks to appoint a Post-Doctoral Research Associate to join the laboratory of Dr Federico Rojas for a period of five years on a BBSRC-funded project. This full-time role will ideally begin in
April 2025.
This research will investigate how the NEDD8 pathway regulates differentiation in
Trypanosoma brucei, specifically the transition from replicative slender forms to cell cycle-arrested (G0/G1) stumpy forms, using genetic and proteomic techniques. Identifying novel components of the neddylation machinery will provide valuable insights into trypanosome biology and has the potential to uncover therapeutic targets. Given the distinct evolutionary position of these parasites, our findings will also contribute to understanding ubiquitin-like modification (UBL) regulation across eukaryotic life.
Role Responsibilities
As part of a dedicated team within our Division, you will be responsible for:
- Collecting and analysing data from genetic and proteomic assays
Coordinating experiments focused on the neddylation machinery in
T. brucei
Designing and implementing experimental protocols using cell culture and molecular biology techniques
Mapping and classifying regulatory mechanisms in the differentiation process
Writing up research findings for publication and conference presentations
Assisting in disseminating project outcomes to key stakeholders
Maintaining ethical and quality standards throughout the study
About You
We are interested in hearing from candidates who have:
- A PhD in Biochemistry, Cell Biology, or a related field
Experience, ideally with but not exclusively, trypanosome cell biology, quantitative proteomics, or molecular biology
Competency in cell culture techniques and data analysis and interpretation
Hands-on experience in handling mice and conducting infection studies in murine models.
Strong organisational skills and attention to detail
Enthusiasm to work collaboratively within a multi-disciplinary team
Why Work with Us
This role is based within the Division of Biomedical and Life Sciences, part of Lancaster University’s Faculty of Health and Medicine. Known for its research excellence, the Division is equipped with Biohazard Category 2 and 3 laboratories, supporting innovative research in health and disease.
Lancaster University is a research-intensive institution, with 99% of its research environment rated as world-leading or internationally excellent in REF 2021. The main Lancaster Bailrigg campus offers numerous on-site amenities, including cafés, a sports centre, multi faith prayer and quiet spaces and scenic green trails and parkland.
We Offer a Competitive Benefits Package, Including
- Competitive salary with annual reviews
Generous employer pension scheme
39 days of annual leave (inclusive of university closure days)
Family-friendly policies supporting work-life balance
Flexible benefits tailored to individual needs
As part of our research team, you will also benefit from:
- A bespoke induction and researcher development programme
Organisational development programmes to expand your research and teaching skills
Ten researcher development days under the Researcher Development Concordat
For an informal discussion about the role, please contact Dr Federico Rojas at federico.rojas@lancaster.ac.uk
Discover more about working at Lancaster University and our benefits at https://www.lancaster.ac.uk/jobs
